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Carbapenemase-producing Enterobacteriaceae (CPE). Know the threat.

What are Carbapenemase-producing Enterobacteriaceae (CPE)?

Carbapenemase-producing Enterobacteriaceae (CPE) are emerging bacteria that have developed resistance to antibiotics, and represent a major threat to both acute and chronic healthcare facilities. CPE are resistant to many carbapenem antibiotics as well as other commonly-prescribed antibiotics.1

CPE can cause difficult-to-treat infections in any part of the body, including pneumonia, bloodstream infections, intra-abdominal infections, urinary tract infections, and central venous catheter infections. Mortality in patients with CPE bacteremia may be up to 50%.2

Close to home

CPE have been identified with increasing frequency in Ontario and in other provinces. According to the Public Health Ontario CPE surveillance program, there was a 2.4-fold increase in the number of positive isolates of CPE from 2012 to 2016 in healthcare facilities.2

Eliminate the threat

Although CPE may be effectively killed on surfaces and equipment in rooms using routine environmental cleaning and disinfection practices, sink and shower drains, toilets and hoppers may be reservoirs for CPE. Persistent colonization of drains can result in CPE transmission to other sinks, and to subsequent room occupants.3,4

Patients may be exposed to organisms that contaminate drains when water splashes from the drain. Splashes may occur when water flow hits a contaminated drain cover or when a toilet or hopper is flushed. Splashes can lead to dissemination of multi-drug resistant organism-containing droplets, which in turn may contaminate the local environment or the skin of nearby healthcare workers and patients.5

Choose cleaning and disinfection products that are effective against CPE

Proper cleaning and disinfection protocols are essential to reduce the risk of CPE transmission in healthcare settings.6 The Clorox company has a range of cleaning and disinfecting products that have been demonstrated to kill CPE within 30 seconds to 2 minutes.

PRODUCTDIN NO.KLEBSIELLA PNEUMONIAE
(KPC)
KLEBSIELLA
PNEUMONIAE (NDM-1)
ESCHERICHIA COLI (CARBAPENEM- RESISTANT)ESCHERICHIA COLI (NDM-1)ENTEROBACTER CLOACAE (NDM-1)
Clorox Healthcare® Bleach Germicidal0246567130 sec30 sec30 sec
Clorox Healthcare® Bleach Germicidal Cleaner024692781 min 1 min 1 min 1 min
Clorox Healthcare® Fuzion® Disinfectant Cleaner
02459744
1 min 1 min
Clorox Healthcare® Hydrogen Peroxide Cleaner Disinfectant0240352830 sec
Clorox Healthcare® Hydrogen Peroxide Cleaner Disinfectant Wipe0240352830 sec30 sec
Clorox Healthcare® VersaSure™ Alcohol-free Cleaner Disinfectant Wipes024731512 min2 min
Clorox Healthcare
Spore Defense Cleaner Disinfectant
024946631 min
Clorox Commercial Solutions
Clorox Total 360
Disinfectant Cleaner
024607692 min2 min

The Clorox company makes products that can kill CPE in 30 seconds

Take the right steps.

Both the Provincial Infectious Diseases Advisory Committee (PIDAC) and the Centers for Disease Control and Prevention (CDC) have issued recommendations on reducing the risks of transmission of multi-drug resistant organisms such as CPE from sinks, drains and plumbing3,5:

  • Daily cleaning and disinfecting surfaces near drains and around sinks, including the sink basin, faucets, faucet handles and the surrounding countertop
  • Avoiding placing patient care items on counters next to sinks
  • Not placing sinks next to medication preparation areas or separating them with splash barriers
  • Preventing faucets from discharging directly above sink strainers
  • Installing sinks that reduce the possibility of splashing
  • Not discarding patient waste or sources of nutrients such as beverages down sinks

The Clorox Company is continually developing advanced and comprehensive solutions that help eliminate CPE and prevent outbreaks.

Learn more about CPE with our guide, available here

References:

  1. De Geyter D, et al. The sink as a potential source of transmission of carbapenemase-producing Enterobacteriaceae in the intensive care unit. Antimicrobial Resistance and Infection Control 2017;6:24-29.
  2. Ontario Ministry of Health and Long-Term Care. Infectious Disease Protocol. Appendix A: Disease-Specific Chapters. Carbepenemase-producing Enterobacteriaceae (CPE) infection and colonization. Accessed September 30, 2020
  3. Ontario Agency for Health Protection and Promotion (Public Health Ontario), Provincial Infectious Diseases Advisory Committee. Best practices for environmental cleaning for prevention and control of infections in all health care settings. 3rd ed. Toronto, ON: Queen’s Printer for Ontario; 2018.
  4. Infection Control Today. Sink traps are surprising source of antibiotic-resistant bacteria in ICU. Accessed October 19, 2020
  5. Centers for Disease Control and Prevention. Healthcare-associated Infections. Reduce Risk from Water. Accessed September 30, 2020.
  6. Public Health Ontario. Frequently Asked Questions: Carbapenemase-producing Enterobacteriaceae (CPE). Accessed September 30, 2020.